Chronic serum sickness glomerulonephritis: Modification of the immune response influences the rate of removal of mesangial electron-dense deposits
作者： Peter N. Furness , David R. Turner
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摘要: We have used a chronic serum sickness model of glomerulonephritis to investigate whether gross interference with the immune system can influence rate removal antigen and established electron-dense deposits from glomerulus. Radio-labelled cationized bovine albumin (BSA) was as antigen. During 2 weeks after cessation injections, isolated glomeruli renal cortex, liver, spleen, lung measured. The mesangial subepithelial assessed by point-counting. Urinary excretion free protein-bound isotope also measured. Having quantified glomerulus, we attempted interfering response in course recovery. Contrary our expectations, stimulation Freund's complete adjuvant, 4 days last injection antigen, inhibited deposits. Prednisolone had no detectable effect, but large doses non-nephritogenic form (native BSA) enhanced removal. Removal inversely correlated levels circulating anti-BSA antibody suggesting that specific antibody, through mesangium, inhibits which is already trapped at site. None forms intervention applied during recovery produced change
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