Visible light induces matrix metalloproteinase-9 expression in rat eye
作者： Andrea M. Papp , Rita Nyilas , Zsuzsanna Szepesi , Magor L. Lőrincz , Eszter Takács
DOI: 10.1111/J.1471-4159.2007.04917.X
关键词:
摘要: Up-regulation of matrix metalloproteinase-9 (MMP-9, gelatinase B) in the nervous system has been demonstrated when excitotoxicity-induced tissue remodeling and neuronal death occurs. Induction MMP-9 by a natural stimulus not observed yet. Using RT-PCR gelatin-zymography we induction at transcriptional protein levels different structures rat eye following over-stimulation with white light. elevation occurred retina without reduction photoreceptor number or major anatomical reorganization. A transient decrease electroretinogram b-wave indicated functional recovery. Retrobulbar injection broad-spectrum MMP-inhibitor GM6001, slowed recovery rate amplitude. Even room-light applied to dark-adapted awake animals induced increase retina, which suggests role for physiological plasticity system, such as light adaptation. This is first demonstration sensory stimulus.
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