Tumor targeting thermosensitive prodrug, and preparation method and application thereof

摘要: The invention provides a tumor targeting thermosensitive prodrug, and preparation method an application thereof. prodrug is expressed by the formula X-(Y-Z)n, wherein X albumin; Z amino-containing antitumor drug; Y biodegradable albumin-drug spacer containing two or more than carboxyls; contains azo group; amino in bonded with carboxyl through amido bond; another n number between 0.05 to 15. applied field of thermo-chemotherapy; thermal response prodrug; compound can be released at fixed point part mechanism; concentration cytoplasm cell nucleus on drug acting greatly increased; drug-fast property overcome; toxic side effects chemotherapy reduced.