Estramustine-induced mitotic arrest in two human prostatic carcinoma cell lines DU 145 and PC-3.
作者： Beryl Hartley-Asp
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摘要: In growth proliferation experiments on two human prostatic carcinoma cell lines, DU 145 cells were found to be more sensitive the cytotoxic effect of estramustine and nor-nitrogen mustard than PC-3 cells. Estramustine was, however, much in both lines mustard. Cytogenetic revealed that produced a drastic increase mitotic index these lines. This could accounted for by arrest their first treatment-metaphase. The arrested metaphases exhibited all characteristics commonly stathmokinetic agents such as colchicine vinca-analogues. No was but chromosomal aberrations at toxic concentrations. Estradiol minimal toxicity caused no induced reversible removal drug.
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