Method for treating cancer by administering IL-15 and IL-15Ralpha complexes
作者： Leo Lefrancois , Thomas A. Stoklasek
DOI:
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摘要: The present invention relates to a therapeutic polypeptide and methods for its creation use modulating an immune response in host organism need thereof. In particular, the administration thereof, of effective amount pre-coupled complex comprising lymphokine portion, example IL-15 (SEQ ID NO: 5, 6), IL-2 10, 12) or combinations both, interleukin receptor IL-15Ra 7, 8), IL-2Ra 9, 11) augmenting system in, example, cancer, SCID, AIDS, vaccination; inhibiting rheumatoid arthritis, Lupus. surprisingly demonstrates increased half-life, efficacy vivo.
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