Low Prevalence of Transmitted Drug Resistance in Patients Newly Diagnosed with HIV-1 Infection in Sweden 2003–2010

摘要: Transmitted drug resistance (TDR) is a clinical and epidemiological problem because it may contribute to failure of antiretroviral treatment. The prevalence TDR varies geographically, its in Sweden during the last decade has not been reported. Plasma samples from 1,463 patients newly diagnosed with HIV-1 infection between 2003 2010, representing 44% all this period, were analyzed using WHO 2009 list mutations for surveillance TDR. Maximum likelihood phylogenetic analyses used determine genetic subtype investigate relatedness sequences. Eighty-two showed evidence TDR, 5.6% (95% CI: 4.5%-6.9%) without any significant time trends or differences infected abroad. Multivariable logistic regression that was positively associated men who have sex (MSM) B negatively CD4 cell counts. Among 54 (68%) had single mutations, whereas five multi-drug resistant HIV-1. Phylogenetic identified nine significantly supported clusters involving 29 including 23 42 (55%) acquired Sweden. One cluster contained 18 viruses M41L mutation, which spread among MSM Stockholm over period at least 16 years (1994-2010). Another cluster, multidrug viruses, also involved Stockholm. 2003-2010 lower than many other European countries. concentrated MSM, where clustering strains observed, highlights need continued improved measures targeted interventions.