Mitochondrial targets of drug toxicity.

摘要: Mitochondria have long been recognized as the generators of energy for cell. Like any other power source, however, mitochondria are highly vulnerable to inhibition or uncoupling harnessing process and run a high risk catastrophic damage The exquisite structural functional characteristics provide number primary targets xenobiotic-induced bioenergetic failure. They also opportunities selective delivery drugs mitochondrion. In light large natural, commercial, pharmaceutical, environmental chemicals that manifest their toxicity by interfering with mitochondrial bioenergetics, it is important understand underlying mechanisms. significance further underscored recent identification control points cell replication differentiation realization play determinant role in signaling apoptotic modes death.