Bone remodeling indices and secondary hyperparathyroidism in celiac disease.

摘要: Objectives : to determine the prevalence of hypovitaminosis D and secondary hyperparathyroidism (SHPT) assess bone turnover by using markers formation resorption in celiac disease (CD). Methods: Forty-three patients with CD were investigated group 1, newly diagnosed celiacs (n = 19) ; 2, treated responding histologically a gluten-free diet 16) 3, refractory celiacs, unresponsive immunosuppressive therapy 8). Serum was drawn for intact parathyroid hormone (PTH), 25-hydroxyvitamin [25(OH)D], ionized calcium (Cai), total alkaline phosphatase (AP), biochemical procollagen I carboxyterminal propeptide (PICP) osteocalcin (Oc). Urinary indices resorption, deoxypyridinoline (DPD), pyridinoline (PyD), hydroxyproline (OHP), measured 2-h fasting urine. In 22 patients, computerized tomographic scan mineral density (BMD) performed. Results The groups respectively, ( 5.4 pmol/L) 25%, 19%, 25%. Bone significantly elevated all groups, compared healthy adults. Low BMD (T-score greater than -1 SD unit) found 68% assessed 36% had T-score -2.5 units. Conclusions: Hypovitaminosis SHPT are common but less those who respond diet. Newly have high state elevation both indices. Those demonstrate remodeling imbalance resorption.