Biological Actions of Endothelin

摘要: Publisher Summary This chapter summarizes the growing amount of information on most potent vasoactive peptide agonist—endothelin. Endothelin is a mediator that generated by endothelial cells exposed to variety injurious or stimulatory conditions. Most organs and tissues possess receptors for endothelin. Several transmembrane signaling pathways are activated after interaction endothelin with its receptor. Elevated tissue plasma levels associated numerous pathophysiological situations. However, no single disease entity appears be exclusively synthesis response(s). Well-documented responses known in both vascular parenchymal cells. The an important molecule cell–cell interactions between sinusoidal hepatocytes, as liver required respond systemic trauma episodes such sepsis specifically hepatic trauma. Hepatic generate this whereas Kupffer cells, Ito hepatocytes which