The Role of Intradermal Skin Testing and Patch Testing in the Diagnosis of Autoimmune Progesterone Dermatitis

摘要: Autoimmune progesterone dermatitis is a rare clinical condition in which patients display hypersensitivity to endogenous progesterone. It manifests as cyclical cutaneous eruption that flares during the luteal phase of menstrual cycle, when levels peak, and resolves partially or completely few days after menses. Its manifestations are variable include urticaria, eczematous eruptions, vesiculopustular fixed drug stomatitis, erythema multiforme, anaphylaxis. has been diagnosed previously with intradermal skin testing intramuscular challenge. Treatment generally consists ovulation inhibition pharmaceutical agents oophorectomy; other therapies (eg, thalidomide) have also used success. We report case multiforme (EM) induced by patient history past oral contraceptive use. After herpes simplex virus was ruled out an etiologic factor, diagnosis confirmed testing. Results subsequent patch various derivatives were negative. The EM outbreaks suppressed temporarily continuous administration Loestrin (ethinyl estradiol plus norethindrone), increased responsiveness prednisone tapers.