Characterization of a Mutated IgA2 Antibody of the m(1) Allotype against the Epidermal Growth Factor Receptor for the Recruitment of Monocytes and Macrophages
作者： Stefan Lohse , Christina Brunke , Stefanie Derer , Matthias Peipp , Peter Boross
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摘要: Background: IgA constitutes a promising antibody isotype, which requires optimization before immunotherapeutic application. Results: P221R-mutated and wild type IgA2m(1) antibodies were similarly effective in killing tumor cells recruiting myeloid effector cells. Conclusion: Improved constitute next generation for therapy. Significance: These studies support the clinical development of therapeutic antibodies.
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Emma Di Carlo, Guido Forni, PierLuigi Lollini, Mario P. Colombo, Andrea Modesti, Piero Musiani, The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood. ,vol. 97, pp. 339- 345 ,(2001) , 10.1182/BLOOD.V97.2.339
Roy Jefferis, Marie-Paule Lefranc, Human immunoglobulin allotypes: possible implications for immunogenicity. mAbs. ,vol. 1, pp. 332- 338 ,(2009) , 10.4161/MABS.1.4.9122
Marielle A. Otten, Jeanette H. W. Leusen, Esther Rudolph, Joke A. van der Linden, Robert H. J. Beelen, Jan G. J. van de Winkel, Marjolein van Egmond, FcR γ-Chain Dependent Signaling in Immature Neutrophils Is Mediated by FcαRI, but Not by FcγRI Journal of Immunology. ,vol. 179, pp. 2918- 2924 ,(2007) , 10.4049/JIMMUNOL.179.5.2918
Marjolein van Egmond, Evert van Garderen, Annemiek B. van Spriel, Cora A. Damen, Edwin S. van Amersfoort, Ger van Zandbergen, Jan van Hattum, Johan Kuiper, Jan G.J. van de Winkel, FcalphaRI-positive liver Kupffer cells: reappraisal of the function of immunoglobulin A in immunity. Nature Medicine. ,vol. 6, pp. 680- 685 ,(2000) , 10.1038/76261
Stefan Lohse, Stefanie Derer, Thomas Beyer, Katja Klausz, Matthias Peipp, Jeanette H. W. Leusen, Jan G. J. van de Winkel, Michael Dechant, Thomas Valerius, Recombinant Dimeric IgA Antibodies against the Epidermal Growth Factor Receptor Mediate Effective Tumor Cell Killing Journal of Immunology. ,vol. 186, pp. 3770- 3778 ,(2011) , 10.4049/JIMMUNOL.1003082
Finn-Eirik Johansen, Ranveig Braathen, Per Brandtzaeg, The J Chain Is Essential for Polymeric Ig Receptor-Mediated Epithelial Transport of IgA Journal of Immunology. ,vol. 167, pp. 5185- 5192 ,(2001) , 10.4049/JIMMUNOL.167.9.5185
Tanja Schneider-Merck, Jeroen J. Lammerts van Bueren, Sven Berger, Kai Rossen, Patrick H.C. van Berkel, Stefanie Derer, Thomas Beyer, Stefan Lohse, Wim K. Bleeker, Matthias Peipp, Paul W. H. I. Parren, Jan G. J. van de Winkel, Thomas Valerius, Michael Dechant, Human IgG2 Antibodies against Epidermal Growth Factor Receptor Effectively Trigger Antibody-Dependent Cellular Cytotoxicity but, in Contrast to IgG1, Only by Cells of Myeloid Lineage Journal of Immunology. ,vol. 184, pp. 512- 520 ,(2010) , 10.4049/JIMMUNOL.0900847
Jantine E. Bakema, Annie Bakker, Simone de Haij, Henk Honing, Madelon Bracke, Leo Koenderman, Gestur Vidarsson, Jan G. J. van de Winkel, Jeanette H. W. Leusen, Inside-out regulation of Fc alpha RI (CD89) depends on PP2A. Journal of Immunology. ,vol. 181, pp. 4080- 4088 ,(2008) , 10.4049/JIMMUNOL.181.6.4080
Marzia Leidi, Elisa Gotti, Luca Bologna, Elena Miranda, Monica Rimoldi, Antonio Sica, Massimo Roncalli, Giuseppe A. Palumbo, Martino Introna, Josée Golay, M2 macrophages phagocytose rituximab-opsonized leukemic targets more efficiently than m1 cells in vitro Journal of Immunology. ,vol. 182, pp. 4415- 4422 ,(2009) , 10.4049/JIMMUNOL.0713732
Annika Ålgars, Heikki Irjala, Samuli Vaittinen, Heikki Huhtinen, Jari Sundström, Marko Salmi, Raija Ristamäki, Sirpa Jalkanen, Type and location of tumor-infiltrating macrophages and lymphatic vessels predict survival of colorectal cancer patients. International Journal of Cancer. ,vol. 131, pp. 864- 873 ,(2012) , 10.1002/IJC.26457