Insights into Soluble Toll-Like Receptor 2 as a Downregulator of Virally Induced Inflammation.

摘要: The ability to distinguish pathogens from self-antigens is one of the most important functions immune system. However, this simple self versus non-self assignment belies complexity response threats. Immune responses vary widely and appropriately according a spectrum threats only recently have mechanisms for controlling highly textured process emerged. A primary mechanism by which controlled decision-making achieved via Toll-like receptor (TLR) signaling subsequent activation coincident with presence pathogenic organisms or antigens, including lipid mediators. While important, appropriate regulation such also critical. Recent findings indicate parallel pathway both viral bacterial infections secretion soluble TLR2 (sTLR2). sTLR2 able bind wide range pathogen-associated molecular patterns (PAMPs) danger-associated (DAMPs). has been detected in many bodily fluids thus ubiquitous sites pathogen appearance. Interestingly, growing evidence suggests that sequester PAMPs DAMPs avoid detection cellular-expressed TLRs. This regulatory function would serve reduce expression molecules required cellular entry, recruitment target cells following infection bacteria viruses. review provides an overview research regarding its properties. Furthermore, role molecule regulating context HIV breast milk actionable insights into therapeutic targets across variety infectious inflammatory states.