ZNF677 Suppresses Akt Phosphorylation and Tumorigenesis in Thyroid Cancer

摘要: The zinc finger protein 677 (ZNF677) belongs to the family, which possesses transcription factor activity by binding sequence-specific DNA. Previous studies have reported its downregulated promoter methylation in non-small cell lung cancer. However, biological role and exact mechanism human cancers, including thyroid cancer, remain unknown. In this study, we demonstrate that ZNF677 is frequently primary papillary cancers (PTC) show decreased expression of significantly associated with poor patient survival. Ectopic cancer cells dramatically inhibited proliferation, colony formation, migration, invasion, tumorigenic potential nude mice induced cell-cycle arrest apoptosis. Conversely, knockdown promoted proliferation formation. exerted tumor suppressor functions through transcriptional repression two targets CDKN3 HSPB1 (or HSP27), thereby inhibiting phosphorylation activation Akt via distinct mechanisms. Taken together, our data as a silenced cancer.Significance: These findings report suppressive zinc-finger inhibition phosphorylation. Cancer Res; 78(18); 5216-28. ©2018 AACR.