Automated Quality Assessment and Image Selection of Ultra-Widefield Fluorescein Angiography Images through Deep Learning.

作者: Henry H. Li , Joseph R. Abraham , Duriye Damla Sevgi , Sunil K. Srivastava , Jenna M. Hach

DOI: 10.1167/TVST.9.2.52

关键词:

摘要: Purpose Numerous angiographic images with high variability in quality are obtained during each ultra-widefield fluorescein angiography (UWFA) acquisition session. This study evaluated the feasibility of an automated system for image classification and selection using deep learning. Methods The training set was comprised 3543 UWFA images. Ground-truth assessed by expert review classified into one four categories (ungradable, poor, good, or best) based on contrast, field view, media opacity, obscuration from external features. Two test sets, including randomly selected 392 separated independent balanced composed 50 ungradable/poor good/best images, model performance bias. Results In assessment showed overall accuracy 89.0% 94.0% distinguishing between gradable ungradable sensitivity 90.5% 98.6% specificity 87.0% 81.5%, respectively. receiver operating characteristic curve measuring two-class (ungradable gradable) had area under 0.920 0.980 set. Conclusions A learning demonstrates automatic quality. Clinical application this might greatly reduce manual grading workload, allow quality-based presentation to clinicians, provide near-instantaneous feedback photographers. Translational Relevance tool may significantly clinical- research-related work, providing instantaneous reliable

参考文章(17)
Philipp Fischer, Thomas Brox, None, U-Net: Convolutional Networks for Biomedical Image Segmentation medical image computing and computer assisted intervention. pp. 234- 241 ,(2015) , 10.1007/978-3-319-24574-4_28
V Manjunath, V Papastavrou, D H W Steel, G Menon, R Taylor, T Peto, J Talks, Wide-field imaging and OCT vs clinical evaluation of patients referred from diabetic retinopathy screening. Eye. ,vol. 29, pp. 416- 423 ,(2015) , 10.1038/EYE.2014.320
Kanishka R. Mendis, Chandrakumar Balaratnasingam, Paula Yu, Chris J. Barry, Ian L. McAllister, Stephen J. Cringle, Dao-Yi Yu, Correlation of histologic and clinical images to determine the diagnostic value of fluorescein angiography for studying retinal capillary detail. Investigative Ophthalmology & Visual Science. ,vol. 51, pp. 5864- 5869 ,(2010) , 10.1167/IOVS.10-5333
Akihiro Ishibazawa, Taiji Nagaoka, Atsushi Takahashi, Tsuneaki Omae, Tomofumi Tani, Kenji Sogawa, Harumasa Yokota, Akitoshi Yoshida, Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study American Journal of Ophthalmology. ,vol. 160, pp. 35- 44.e1 ,(2015) , 10.1016/J.AJO.2015.04.021
Szilárd Kiss, Thomas L. Berenberg, Ultra Widefield Fundus Imaging for Diabetic Retinopathy Current Diabetes Reports. ,vol. 14, pp. 514- ,(2014) , 10.1007/S11892-014-0514-0
Matthew M. Wessel, Grant D. Aaker, George Parlitsis, Minhee Cho, Donald J. DʼAmico, Szilárd Kiss, Ultra-wide-field angiography improves the detection and classification of diabetic retinopathy. Retina-the Journal of Retinal and Vitreous Diseases. ,vol. 32, pp. 785- 791 ,(2012) , 10.1097/IAE.0B013E3182278B64
Le Zhang, Ali Gooya, Bo Dong, Rui Hua, Steffen E. Petersen, Pau Medrano-Gracia, Alejandro F. Frangi, Automated Quality Assessment of Cardiac MR Images Using Convolutional Neural Networks International Workshop on Simulation and Synthesis in Medical Imaging. pp. 138- 145 ,(2016) , 10.1007/978-3-319-46630-9_14
Varun Gulshan, Lily Peng, Marc Coram, Martin C. Stumpe, Derek Wu, Arunachalam Narayanaswamy, Subhashini Venugopalan, Kasumi Widner, Tom Madams, Jorge Cuadros, Ramasamy Kim, Rajiv Raman, Philip C. Nelson, Jessica L. Mega, Dale R. Webster, Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs JAMA. ,vol. 316, pp. 2402- 2410 ,(2016) , 10.1001/JAMA.2016.17216
Mayss Al-Sheikh, Khalil Ghasemi Falavarjani, Handan Akil, SriniVas R. Sadda, Impact of image quality on OCT angiography based quantitative measurements International Journal of Retina and Vitreous. ,vol. 3, pp. 13- 13 ,(2017) , 10.1186/S40942-017-0068-9
Justis P Ehlers, Kevin Wang, Amit Vasanji, Ming Hu, Sunil K Srivastava, Automated quantitative characterisation of retinal vascular leakage and microaneurysms in ultra-widefield fluorescein angiography British Journal of Ophthalmology. ,vol. 101, pp. 696- 699 ,(2017) , 10.1136/BJOPHTHALMOL-2016-310047