Hepatitis C virus infection in patients receiving opiate substitution therapy in Sweden.

摘要: The hepatitis C virus (HCV) is a blood borne effectively spread through injection practices. Consequently, people who inject drugs (PWID) are at the center of current HCV epidemic in industrialized countries, with regards both to prevalence and incidence. Through progressive liver fibrosis, chronic infection conveys substantial risk cirrhosis end-stage disease. These complications can be prevented by successful treatment resulting clearance. uptake has hitherto been low among PWID, due barriers on patient- as well health care provider levels. PWID also have multitude other factors affecting morbidity mortality. major causes death directly drug related. Opiate substitution therapy (OST) reduces related mortality heroin using which might allow for conditions, such infection, impact OST improves social functioning shown improve outcomes users, hence clinics could serve important points contact management. aim this thesis was investigate different aspects Swedish recipients. In cross-sectional multi study receiving patients Stockholm, Gothenburg Malmo we assessed burden severity fibrosis relation potential factors. We evaluated feasibility peginterferon/ribavirin based treatment, same cohort, special attention psychiatric status quality life (HRQoL). register exposure users recruited from needle exchange program. cohort found high rates (88% anti-HCV positive) 67% viremic showed significant association alcohol intake, elevated BMI B virus. treated subjects observed completion (83%) SVR (46%) line previous reports spite scores HRQoL occurrence depression already baseline. population program significantly (HR 3.08, 95%CI (1.09, 8.68), p=0.03) exposure. conclusion, disease problem may an increasingly common cause death. Thus, targeted management progression should integral part comprehensive provided clinics. Our findings satisfactory holds promise even higher once new interferon free regimens efficacy, less toxicity shorter duration, implemented. However, more efficient therapies able mortality, increasing assessment recipients essential