Immune Intervention in Tuberculosis

摘要: Regardless of the theoretical attraction immune intervention in tuberculosis and although Mycobacterium bovis Bacille Calmette Guerin (BCG) provides a mainstay global vaccination campaigns, current efforts control are almost exclusively directed toward implementation antimicrobial therapy. This chapter reviews prospects for changing this situation by developing improved interventions. BCG some hard lessons would-be developers new vaccines. On positive side, it vindicates concept as an approach to control. While precise numbers obtain, seems reasonable extrapolate that has saved lives millions potential victims childhood tuberculosis. In experimental-animal models, conforms paradigm. naive animals, population M. increases several weeks after infection before being brought under response. Mycobacteria provide potent signal innate system, with cell wall components triggering scavenger Toll-like receptors on surface, activating NF-κB transduction pathways leading secretion IL-12 proinflammatory cytokines. If vaccine was be compared BCG, consideration would also have given question withdrawing coverage from part trial group, perhaps increasing their risk potentially fatal The natural response may well been shaped much evolutionary needs microbe those host.