A Critical Role of GIT1 in Vertebrate and Invertebrate Brain Development
作者： Sung-Tae Hong , Won Mah
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摘要: GIT1, a multifunctional signaling adaptor protein, is implicated in the development of dendritic spines and neuronal synapses. GIT1 forms complex with PIX, RAC, PAK proteins that known to play important roles brain development. Here we found Git1-knockout (Git1-/-) mice show microcephaly-like small phenotype, which appears be caused by reduced size rather than number. Git1-/- also decreased spine number without morphological alterations hippocampus. Behaviorally, impaired motor coordination learning memory. In addition, adult dGit Drosophila mutants abnormal morphology mushroom body. These results suggest for both rodents flies.
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