Overview of Epstein-Barr-Virus-Associated Gastric Cancer Correlated with Prognostic Classification and Development of Therapeutic Options.

摘要: Gastric cancer (GC) is a deadly disease with poor prognosis that characterized by heterogeneity. New classifications based on histologic features, genotypes, and molecular phenotypes, for example, the Cancer Genome Atlas subtypes those Asian Research Group, help understand carcinogenic differences in GC have led to identification of an Epstein-Barr virus (EBV)-related subtype (EBVaGC), providing new indications tailored treatment prognostic factors. This article provides review features EBVaGC update latest insights from EBV-related research particular focus strict interaction between EBV infection gastric tumor environment, including host immune response. information may increase our knowledge pathogenesis mechanisms sustain response patients since this mechanism has been demonstrated offer survival advantage proportion GC.