作者: Melly S Oitzl , Marc Fluttert , E.Ron de Kloet
DOI: 10.1016/S0006-8993(98)00387-4
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摘要: Corticosteroids can facilitate or impair learning and memory processes. We found that the glucocorticoid receptor antagonist RU38486 injected locally into dorsal hippocampus dose-dependently improved performance of male Wistar rats in water maze 24 h after treatment. This observation suggests a discrete specificity hippocampal receptors facilitation memory.