Acute blockade of hippocampal glucocorticoid receptors facilitates spatial learning in rats.

作者: Melly S Oitzl , Marc Fluttert , E.Ron de Kloet

DOI: 10.1016/S0006-8993(98)00387-4

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摘要: Corticosteroids can facilitate or impair learning and memory processes. We found that the glucocorticoid receptor antagonist RU38486 injected locally into dorsal hippocampus dose-dependently improved performance of male Wistar rats in water maze 24 h after treatment. This observation suggests a discrete specificity hippocampal receptors facilitation memory.

参考文章(20)
Aernout D. van Haarst, Melly S. Oitzl, E. Ronald de Kloet, Facilitation of Feedback Inhibition Through Blockade of Glucocorticoid Receptors in the Hippocampus Neurochemical Research. ,vol. 22, pp. 1323- 1328 ,(1997) , 10.1023/A:1022010904600
M S Oitzl, E R de Kloet, Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning. Behavioral Neuroscience. ,vol. 106, pp. 62- 71 ,(1992) , 10.1037//0735-7044.106.1.62
Demitri F. Papolos, Emmeline Edwards, Ronen Marmur, Herbert M. Lachman, Fritz A. Henn, Effects of the antiglucocorticoid RU 38486 on the induction of learned helpless behavior in Sprague-Dawley rats Brain Research. ,vol. 615, pp. 304- 309 ,(1993) , 10.1016/0006-8993(93)90042-L
Melly S. Oitzl, E. Ron de Kloet, Marian Joëls, Wolfgang Schmid, Timothy J. Cole, Spatial Learning Deficits in Mice with a Targeted Glucocorticoid Receptor Gene Disruption European Journal of Neuroscience. ,vol. 9, pp. 2284- 2296 ,(1997) , 10.1111/J.1460-9568.1997.TB01646.X
E. Ronald De Kloet, Stan De Kock, Victor Schild, H. Dick Veldhuis, Antiglucocorticoid RU 38486 attenuates retention of a behaviour and disinhibits the hypothalamic-pituitary adrenal axis at different brain sites. Neuroendocrinology. ,vol. 47, pp. 109- 115 ,(1988) , 10.1159/000124900
Anna Ratka, Winardi Sutanto, Margreet Bloemers, Ronald de Kloet, On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation. Neuroendocrinology. ,vol. 50, pp. 117- 123 ,(1989) , 10.1159/000125210
Melly S. Oitzl, Marc Fluttert, Win Sutanto, E. Ron De Kloet, Continuous blockade of brain glucocorticoid receptors facilitates spatial learning and memory in rats European Journal of Neuroscience. ,vol. 10, pp. 3759- 3766 ,(1998) , 10.1046/J.1460-9568.1998.00381.X
James L. McGaugh, Grace Portillo-Marquez, Benno Roozendaal, Basolateral amygdala lesions block glucocorticoid-induced modulation of memory for spatial learning. Behavioral Neuroscience. ,vol. 110, pp. 1074- 1083 ,(1996) , 10.1037//0735-7044.110.5.1074