Chemomodulatory Effect of Moringa Oleifera, Lam, on Hepatic Carcinogen Metabolising Enzymes, Antioxidant Parameters and Skin Papillomagenesis in Mice

摘要: The modulatory effects of a hydro-alcoholic extract drumsticks Moringa oliefera Lam at doses 125 mg/kg bodyweight and 250 mg/ kg body weight for 7 14 days, respectively, were investigated with reference to drug metabolising Phase I (Cytochrome b(5) Cytochrome p(450) ) II (Glutathione-S- transferase) enzymes, anti-oxidant glutathione content lipid peroxidation in the liver 6-8 week old female Swiss albino mice. Further, chemopreventive efficacy was evaluated two stage model 7,12 - dimethylbenz(a)anthracene induced skin papillomagenesis. Significant increase (p<0.05 p<0.01) activities hepatic cytochrome b(5), p(450), catalase, peroxidase ( GPx ), reductase (GR), acid soluble sulfhydryl (-SH significant decrease p<0.01 MDA level observed both dose levels treatment when compared control values. Glutathione-S- transferase GST )activity found be significantly increased (p<0.01 only higher level. Butylated hydroxyanisol (BHA fed 0.75% diet days (positive caused phase anti- oxidant peroxidation. papillomagenesis studies demonstrated percentage mice papillomas, average number papillomas per mouse papilloma bearing animals received topical application 5mg/ peri-initiation before after DMBA application, Group promotional (from day croton oil continued till end experiment, III peri post initiation stages prior IV) group (Group ). inhibition tumor multiplicity has been recorded 27, 72, 81 Groups II, III, IV, respectively. These findings are suggestive possible potential drumstick against chemical carcinogenesis.