Direct Cell Writing of 3D Microorgan for In Vitro Pharmacokinetic Model
作者： Robert Chang , Jae Nam , Wei Sun
DOI: 10.1089/TEN.TEC.2007.0392
关键词:
摘要: A novel targeted application of tissue engineering is the development an in vitro pharmacokinetic model for drug screening and toxicology. An needed to realistically reliably predict vivo human response administrations potential toxic exposures. This paper details fabrication process adaptation microfluidic devices creation such a physiologically relevant model. First, automated syringe-based, layered direct cell writing (DCW) bioprinting creates 3D microorgan that biomimics cell's natural microenvironment with enhanced functionality. Next, soft lithographic micropatterning techniques are used fabricate microscale device house microorgan. demonstrates feasibility DCW freeform biofabrication cell-encapsulated hydrogel-based constructs defined reproducible patterns, integration onto mic...
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