Non-ulcer dyspepsia and short term De-Nol therapy: a placebo controlled trial with particular reference to the role of Campylobacter pylori.

摘要: This double blind randomised study tested the effectiveness of colloidal bismuth subcitrate (De-Nol) in non-ulcer dyspepsia (NUD) and if any benefit is associated with clearance Campylobacter pylori (C pylori) from gastric mucosa. Sixty six patients dyspepsic symptoms, normal abdominal ultrasound, upper GI endoscopy, were randomly allocated to placebo or De-Nol for eight weeks. Antral biopsies taken bacteriological histological examination, endoscopies clinical questionnaires administered before after treatment. Fifty two (25 on 27 placebo) completed trial. cleared C 10 12 positive (83.3%), whereas did not clear (p less than 0.01). In receiving gastritis improved 0.01) symptomatic response was better 0.001) compared placebo. group seven 19 negative became positive: this significant deterioration a phenomenon seen treated group.