INFLUENCE OF ACETYLSALICYLIC ACID, AN INHIBITOR OF PROSTAGLANDIN SYNTHESIS, ON THE DURATION OF HUMAN GESTATION AND LABOUR

作者: RichardB. Lewis , JosephD. Schulman

DOI: 10.1016/S0140-6736(73)92934-6

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摘要: Abstract A retrospective survey of 103 patients taking high-dose acetylsalicylic acid for at least the last 6 months pregnancy has been carried out and comparisons made with control populations. Aspirin administration was associated a highly significant increase in average length gestation, frequency postmaturity, mean duration spontaneous labour. These observations are compatible known capacity aspirin to inhibit synthesis prostaglandins, suggest that endogenous prostaglandins important regulators human gestation The possibility is raised aberrations prostaglandin metabolism could be responsible certain instances postmaturity or prolonged

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