Regulation of chromatin structure and gene activity by poly(ADP-ribose) polymerases.
作者： Alexei Tulin , Yurii Chinenov∗ , Allan Spradling
DOI: 10.1016/S0070-2153(03)01007-X
关键词:
摘要: Poly(ADP-ribose) polymerase 1 (PARP1) is an abundant nuclear protein that plays important role in repairing DNA and responding to infection. Here we review recent evidence PARP1 related proteins also carry out crucial functions regulating genes during normal development. Genetic studies mammals Drosophila have implied PARPs mediate rapid responses environmental stimuli, including infection, stress, hormones, growth signals. In addition, these polymerases may control fundamental processes differentially mold remodel chromatin within the many cell types of a developing embryo. We discuss unified mechanism PARP action repair, gene transcription, modulation.
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