Increase of Proliferating Renal Progenitor Cells in Acute Tubular Necrosis Underlying Delayed Graft Function

摘要: Background. Delayed graft function (DGF) is associated with acute tubular necrosis. In this setting, surviving cells may proliferate and replace injured cells. CD133 + Pax-2 play a role in the regeneration of damage. The aim study was to demonstrate presence these human kidneys before transplantation grafts DGF. Methods. Ten normal (group 1) pretransplant biopsy 25 deceased donors 2) were examined. latter group included 10 early (2A) 15 DGF (2B). Group 2B patients received second during (2C). CD 133, Pax-2, Ki-67 protein expression investigated by confocal microscopy. Results. - present within Bowman's capsule proximal tubules all groups except 2B. Number at level similar 1 2A. Within we observed striking reduction both cell types. There significant increase populations 2C, compared number 2 correlated inversely cold ischemia time. absent from samples, increased significantly 2A 2C. Proliferating Conclusions. Our data suggest that regenerative response posttransplant necrosis, underlying DGF, characterized an proliferating renal progenitor/stem involved repairing