Significant Association Between MTHFR C677T Polymorphism and Thyroid Cancer Risk: Evidence from a Meta-Analysis
作者： Ying Chen , Bin Wang , Shengli Yan , Yan-Gang Wang
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摘要: Background: Many studies were published to assess the associations of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with thyroid diseases, including cancer, but results controversial. Methods: A comprehensive search was performed in Pubmed, Embase, and Chinese Biomedical Database (CBM) databases or investigating MTHFR diseases. Odds ratios (OR) 95% confidence intervals (95% CI) used possible associations. Results: Nine a total 2421 individuals finally included into meta-analysis. Meta-analysis nine showed that there no association between diseases (OR T vs. C=1.09, CI 0.94–1.26, p=0.25; OR TT CC=1.04, 0.75–1.42, p=0.83; CC/CT=1.13, 0.86–1.50, p=0.37; TT/CT CC=1.22, 0.88–1.68, p=0.24). on cancer an obvi...
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