Anti-Inflammatory Effects of Epoxyeicosatrienoic Acids

摘要: Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid inactivated largely soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic (DHETs). EETs have been shown a diverse range effects vasculature including relaxation vascular tone, cellular proliferation, angiogenesis as well migration smooth muscle cells. This paper will highlight growing evidence that mediate number anti-inflammatory in cardiovascular system. In particular, numerous studies demonstrated potentiation EET using different methods can inhibit inflammatory gene expression signalling pathways endothelial cells monocytes models diseases. The mechanisms unknown but may include direct binding peroxisome proliferator-activated receptors (PPARs), G-protein coupled (GPCRs), or transient receptor potential (TRP) channels, initiate cascades.