Synthesis of conjugated bile acids/azastilbenes as potential antioxidant and photoprotective agents
作者： Juliana Alves dos Santos , Hudson Caetano Polonini , Érika Yoko Suzuki , Nádia RB Raposo , Adilson David da Silva
DOI: 10.1016/J.STEROIDS.2015.03.009
关键词:
摘要: Abstract A series of 14 bile acids/azastilbenes conjugates ( 1a–g and 2a–g ) was prepared through the condensation amides 1 2 aromatic aldehydes. The newly synthesized were evaluated in vitro for their antioxidant photoprotective activities. Six compounds , 1a 1b 2a 2b showed promising activity with IC 50 values 19.60–31.83 μg mL −1 . presented a varied photoprotection profile, SPF ranging from to 9. Among 16 tested protection against UVB sunrays, 3 2c 2e 2g more significant than resveratrol free azastilbene ; while UVAPF increased 5 5–11 majority conjugates.
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