Allergy and worms: let’s bring back old friends?

摘要: In order to survive in their host, parasitic worms (helminths) have evolved cunning strategies manipulate the host immune system, some of which may lead protection from dysregulatory diseases such as allergy. Thus, loss exposure helminths due a highly hygienic life style might contributed fact that living an industrialized country is being associated with increased prevalence allergic diseases. However, it must be pointed out certain helminth infections can induce phenotype. Factors different parasite species, timing infection relation sensitization, or duration and intensity influence association between development clinical course disease. present article, we review studies explored interaction allergy epidemiological experimental studies. Furthermore, possibility using helminth-derived molecules for treatment discussed focus on evidence trials. During past 10 years, many exciting important found protect against Not surprisingly, several trials investigated effects deliberate parasites like porcine whipworm (Trichuris suis) hookworm (Necator americanus) develop “helminth therapies”. Although they proved safe option control aberrant inflammation, final goal identify parasite-derived immunnomodulatory responsible protective effects.