Résistance à l'infection par les trypanosomes Africains chez l'homme.

摘要: African trypanosomes (prototype: Trypanosoma brucei) are protozoan flagellates that infect a wide range of different mammals. In humans, these parasites have to counteract innate immunity because human serum possesses efficient trypanolytic activity. Resistance this activity has arisen in two T. brucei subspecies, termed b. rhodesiense and gambiense, allowing them humans where they cause sleeping sickness East West Africa respectively. The study the mechanism by which escapes lysis led identification factor, turned out be an ionic pore-forming apolipoprotein associated with some HDL particles.