Carcinoembryonic Antigen, Squamous Cell Carcinoma Antigen, CYFRA 21-1, and Neuron-specific Enolase in Squamous Cell Lung Cancer Patients

摘要: Background: Carcinoembryonic antigen (CEA), squamous cell carcinoma (SCC-Ag), and CYFRA 21-1 are the most useful markers for non-small lung cancer (NSCLC), but neuron-specific enolase (NSE) is a tumor maker of choice SCLC. The determination NSE in NSCLC could allow selection patients with neuroendocrine features. whose tumors have properties may be more responsive to chemotherapy; however, these been reported aggressive. Tumor not suitable diagnosis; their principal applications monitoring therapy prognosis. Methods: were measured 200 untreated (SQC) reference group (n = 220; 124 healthy persons 96 nonmalignant disease). CEA SCC-Ag by microparticle enzyme immunoassays on Abbott AxSYM IMx analyzers. electrochemiluminescence Roche Elecsys 2010. Results: CEA, SCC-Ag, 21-1, increased above cutoffs 26%, 32%, 67%, 28% tested patients, respectively. area under ROC curve was higher than those (SQC vs controls). significantly advanced SQC early stages disease ( P <0.0001 <0.0004, respectively). In multivariate analysis survival, an independent nonspecific prognostic factor operable whereas disease. Conclusion: earlier SQC.