Functional MRI study of specific animal phobia using an event-related emotional counting stroop paradigm.
作者： Jennifer C. Britton , Andrea L. Gold , Thilo Deckersbach , Scott L. Rauch
DOI: 10.1002/DA.20569
关键词:
摘要: Background: Emotional interference tasks may be useful in probing anterior cingulate cortex (ACC) function to understand abnormal attentional study individuals with specific phobia. Methods: In a 3 T functional MRI study, phobias of the animal subtype (SAP, n=12) and healthy comparison (HC) adults (n=12) completed an event-related emotional counting Stroop task. Individuals were presented phobia-related, negative, neutral words instructed report via button press number displayed on each trial. Results: Compared HC group, SAP group exhibited greater rostral ACC activation (i.e., response phobia-related than words). this same contrast, HCs right amygdala posterior insula activations as well thalamic deactivation group. Both groups cingulate, dorsomedial prefrontal cortex, inferior frontal gyrus/insula, deactivation. Psychophysiological interaction analysis highlighted network these regions Conclusions: Taken together, findings implicate circuit dysfunction, which is linked attention abnormalities SAP. Depression Anxiety, 2009. Published 2009 Wiley-Liss, Inc.
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