Non-invasive screening of lung nodules in mice comparing a novel volumetric computed tomography with a clinical multislice CT.

摘要: In vivo imaging of small animal models will play an increasingly important role in cancer research, as new systems that employ non-invasive protocols and offer high-resolution capability become available. A flat-panel volumetric computed tomograph (fpvCT) was evaluated to determine if minimally invasive can be used provide the spatial resolution required for lung animals. The detection pulmonary nodules a Lewis carcinoma model investigated, fpvCT compared with multislice (MSCT). Five C57/BL6 mice were monitored both modalities over two weeks. Sensitivity measured by comparing results histology, incidence first visualization tumors determined. Compared MSCT, proved its superior sensitivity nodules. Due isotropic significant reduction partial volume effects, early reasonable determination growth very only possible fpvCT. is system ability perform monitoring tumor mice. This permits longitudinal investigations animals research.