Alignment of whole genomes

作者: A. L. Delcher , S. Kasif , R. D. Fleischmann , J. Peterson , O. White

DOI: 10.1093/NAR/27.11.2369

关键词:

摘要: A new system for aligning whole genome sequences is described. Using an efficient data structure called a suffix tree, the able to rapidly align containing millions of nucleotides. Its use demonstrated on two strains Mycoplasma tuberculosis, less similar species bacteria and syntenic from human chromosome 12 mouse 6. In each case it found alignment input sequences, using between 30 s 2 min computation time. From output, information single nucleotide changes, translocations homologous genes can easily be extracted. Use algorithm should facilitate analysis chromosomal regions, strain-to-strain comparisons, evolutionary comparisons genomic duplications.

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