Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts.
作者： T. Lieke , C. Steeg , S. E. B. Graefe , B. Fleischer , T. Jacobs
DOI: 10.1111/J.1365-2249.2006.03118.X
关键词:
摘要: Summary The protozoan parasite Trypanosoma cruzi circulates in the blood as trypomastigotes and invades a variety of cells to multiply intracellularly amastigotes. The acute phase triggers an immune response that restricts proliferation parasite. However, parasites are able persist different tissues causing pathology Chagas’ disease. Natural killer (NK) play important role innate resistance pathogens. In present study we demonstrate NK trigger trypanocidal mechanisms infected L929 critically dependent on inducible nitric oxide (NO) synthase (iNOS) induction which is, major degree, triggered by interferon (IFN)-γ provided cells. This work provides more detailed analysis how part system participate control reside fibroblast-like
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