The Nocardia cyriacigeorgica GUH-2 genome shows ongoing adaptation of an environmental Actinobacteria to a pathogen’s lifestyle

摘要: Nocardia cyriacigeorgica is recognized as one of the most prevalent etiological agents human nocardiosis. Human exposure to these Actinobacteria stems from direct contact with contaminated environmental matrices. The full genome sequence N. strain GUH-2 was studied infer major trends in its evolution, including acquisition novel genetic elements that could explain ability thrive multiple habitats. size 6.19 Mb-long, 82.7% CDS have homologs at least another actinobacterial genome, and 74.5% are found farcinica. Among specific CDS, some likely implicated niche specialization such those involved denitrification RuBisCO production, regions genomic plasticity (RGP). Overall, 22 RGP were identified this representing 11.4% content. Some encode a recombinase IS which indicative instability. playing part virulence mammalian cell entry or encoding superoxide dismutase. non ribosomal peptide synthetases (NRPS) polyketide synthases (PKS) identified, being synthesis siderophores toxins. COG analyses showed an organization similar Actinobacteria. shows features suggesting diversification ancestral saprophytic state. acquiring foreign DNA significant led functional changes beneficial for cycle opportunistic colonization host.