Therapeutic Insights against Oxidative Stress Induced Diabetic Nephropathy: A Review

摘要: Diabetes mellitus (DM) is an outcome of absolute or relative deficiency insulin which may be due to autoimmune destruction. It mainly characterised by hyperglycemia, causes auto-oxidation glucose, glycation proteins and activation polyol mechanism. This leads oxidative stress, defined as increase in the intracellular level reactive oxygen species (ROS). Overproduction ROS contributes several microvascular macrovascular complications DM including diabetic nephropathy (DN). DN a primary cause chronic kidney disease end-stage renal failure various parts world. Minimizing risk factors associated with insufficient lowering vulnerability this disorder. Henceforth, increased knowledge on role stress would lead way exploration number molecules having antioxidant property therapeutic option. These agents could reduce severity decreasing modulating array signalling cascade, thereby ameliorating via its antioxidative immunomodulatory properties. review provides valuable information concerning recent advancements understanding well-known alleviating induced renovascular DM. also encompasses different natural products their effect T-cell driven immune response nephropathy.