Difficult‐to‐Control Asthma and Obstructive Sleep Apnea

摘要: This study tested the hypothesis that asthma can promote obstructive sleep apnea (OSA) by looking at prevalence of OSA among patients with difficult-to-control receiving long-term oral corticosteroid (CS) therapy and examined some possible etiological factors. The design was a prospective cohort conducted in pulmonary outpatient clinic tertiary care center Haifa, Israel. Twenty-two consecutive severe unstable asthma, 14 on continuous 8 bursts CS, addition to their standard for mean 8.9 +/- 3.3 years, underwent night polysomnography laboratory regardless complaints. A questionnaire completed upon attending laboratory. defined as respiratory disturbance index (RDI) > or = 5 typical correlation between RDI morphometric parameters tested. All but one patient had [95.5% prevalence], 17.7 2.5. values were significantly higher CS subgroup (21.4 3.4 vs. 11.1 1.6, p < 0.05]. group above normal neck circumferences body mass index. former increased 12.1% 3.1% % 29.8% 1% during interval no significant effect covariant. showed an unexpectedly high chronic frequent burst therapy. It may be assumed prolonged especially increases airway collapsibility.