Long-Term Durability of Crohn’s Disease Treatment with Infliximab

摘要: Background There is a paucity of data providing insight into the durability Crohn’s disease treatment with infliximab for periods longer than 12 months. Our aim was to assess long-term therapy. Materials and Methods A total 198 Crohn's patients under maintenance regimen infliximab, at least 30-month follow-up, were evaluated retrospectively. Long-term response estimated using Kaplan-Meier analysis. The effect specific variables calculated logistic regression proportional hazard analyses. Results Maintenance rates 72 months be 66.4% initial responders 58.2% all treated. Concurrent immunomodulators enhanced in treated, particularly if started >3 before initiation Smoking significantly decreased responders. Conclusions Infliximab reasonably durable beyond immunosuppressive therapy may increase – smoking decrease maintenance.