Epigenetic Signaling in Glia Controls Presynaptic Homeostatic Plasticity
作者： Tingting Wang , Danielle T. Morency , Nathan Harris , Graeme W. Davis
DOI: 10.1016/J.NEURON.2019.10.041
关键词:
摘要: Summary Epigenetic gene regulation shapes neuronal fate in the embryonic nervous system. Post-embryonically, epigenetic signaling within neurons has been associated with impaired learning, autism, ataxia, and schizophrenia. factors are also enriched glial cells. However, little is known about glia nothing intersection of presynaptic homeostatic plasticity. During a screen for genes involved synaptic plasticity, we identified an essential role histone acetyltransferase deubiquitinase SAGA complex peripheral glia. We present evidence that necessary demonstrating involvement four new This is also participate invoking previously unexplored intercellular, at tripartite synapse. show, mechanistically, regulates composition from extracellular matrix during
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