Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action of diazepam
作者： C. C. Mao , A. Guidotti , E. Costa
DOI: 10.1007/BF00508411
关键词:
摘要: Subcutaneous injections of isoniazid or picrotoxin increase the cerebellar content 3′,5′-cyclic guanosine monophosphate (cGMP) without changing adenosine cAMP. This was dose dependent and threshold for cGMP lower than that convulsions. In cerebellum elicited by but not caused paralleled a decrease GABA content.
springer.com
sci-hub.se 参考文章(19)
Graham A. R. Johnston, David R. Curtis, Amino acid transmitters in the mammalian central nervous system Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie. ,vol. 69, pp. 97- 188 ,(1974) , 10.1007/3-540-06498-2_3
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Gerhard Zbinden, Lowell O. Randall, Pharmacology of benzodiazepines: laboratory and clinical correlations. Advances in pharmacology. ,vol. 5, pp. 213- 291 ,(1967) , 10.1016/S1054-3589(08)60658-4
A. Guidotti, D.L. Cheney, M. Trabucchi, M. Doteuchi, C. Wang, R.A. Hawkins, Focussed microwave radiation: a technique to minimize post mortem changes of cyclic nucleotides, dopa and choline and to preserve brain morphology Neuropharmacology. ,vol. 13, pp. 1115- 1122 ,(1974) , 10.1016/0028-3908(74)90061-6
C.C. Mao, A. Guidotti, E. Costa, Inhibition by diazepam of the tremor and the increase of cerebellar cGMP content elicited by harmaline Brain Research. ,vol. 83, pp. 516- 519 ,(1975) , 10.1016/0006-8993(75)90846-X
R.A. Nicoll, A. Padjen, Pentylenetetrazol: an antagonist of GABA at primary afferents of the isolated frog spinal cord. Neuropharmacology. ,vol. 15, pp. 69- 71 ,(1976) , 10.1016/0028-3908(76)90099-X
P. Polc, H. M�hler, W. Haefely, The effect of diazepam on spinal cord activities: Possible sites and mechanisms of action Naunyn-Schmiedeberg's Archives of Pharmacology. ,vol. 284, pp. 319- 337 ,(1974) , 10.1007/BF00504702
Hans Corrodi, Kjell Fuxe, Peter Lidbrink, Lars Olson, Minor tranquillizers, stress and central catecholamine neurons Brain Research. ,vol. 29, pp. 1- 16 ,(1971) , 10.1016/0006-8993(71)90413-6
Amin Suria, E. Costa, Action of diazepam, dibutyryl cGMP, and GABA on presynaptic nerve terminals in bullfrog sympathetic ganglia. Brain Research. ,vol. 87, pp. 102- 106 ,(1975) , 10.1016/0006-8993(75)90787-8
E. Costa, A. Guidotti, C.C. Mao, A. Suria, New concepts on the mechanism of action of benzodiazepines. Life Sciences. ,vol. 17, pp. 167- 185 ,(1975) , 10.1016/0024-3205(75)90501-9