The role of stj fimbrial operon in the intestinal persistence of Salmonella Typhimurium in mice
作者： Nefise Akkoç , Banu Özden , Begüm Tan , Mustafa Akçelik
DOI: 10.2478/S11756-009-0170-Z
关键词:
摘要: Salmonella Typhimurium contains 13 operons coding for fimbriae with unique binding specificities to host epithelial surfaces. stj operon is only detected in S. genome suggesting that Stj fimbria may effect serovarspecific virulence characteristics. In this study, the role of fimbrial long-term persistence was identified by competitive infection experiment genetically resistant mouse (CBA) model system. Knock-out mutation stjA (major subunit fimbria) gene reduced recovery from fecal samples and its colonization spleen, cecum mesenteric lymph nodes over a 34-day time period (p < 0.05). This data indicate has intestinal CBA mice.
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