The Alzheimer Tangle and Aging

摘要: Attempts to formulate Alzheimer’s disease as a manifestation of general brain aging make assumptions about the nature Alzheimer tangle which may not be supported by closer study. Thus it is often thought that because tangle-like structures appear in course number neurological disorders (Yagashita et al, 1979; Ishi 1981; Hirano 1983), consequence repeated injury dementia pugilistica (Corsellis 1973), or intoxication with aluminium salts (Wisniewski 1982), classical non-specific disturbance cortical pyramidal cell function. Indeed well established relationship between increasing age (over 60 years) and an frequency plaques neurofibrillary tangles brains cognitively normal subjects (Tomlinson 1968) has led some speculate these lesions even represent measure “force senescence” man (Dayan, 1970).