The emergence of Parkinson disease among patients with Gaucher disease

摘要: In the last decade, several lines of evidence have been presented that document clinical manifestations, genetic associations, and sub-cellular mechanisms inter-relatedness β-glucocerebrosidase mutations emergence Parkinson disease among carriers patients with Gaucher disease. This review is an attempt to apprise reader recent literature caveat this area intensive exploration constantly being updated because immediate ramifications but also impact on our understanding disease, finally unexpected inter-reactions between these entities molecular level. It has happenstance it discovered a rare monogenetic interface at many points neurological disorder elderly both familial sporadic forms: date there no cure for either disorders.