Pathway engineering for the production of aromatic compounds in Escherichia coli
作者： Noemí Floras , Jimmy Xiao , Alan Berry , Francisco Bolivar , Fernando Valle
DOI: 10.1038/NBT0596-620
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摘要: Glucose is the preferred substrate for certain fermentation processes. During its internalization and concomitant formation of glucose-6-phosphate through the glucose phosphotransferase system (PTS), one molecule of phosphoenolpyruvate (PEP) is consumed. Together with erythrose 4-phosphate (E4P), PEP is condensed to form 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAMP), the first intermediate of the common segment of the aromatic pathway. From this metabolic route, several commercially important …
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sci-hub.se 参考文章(19)
W.H. HOLMS, The Central Metabolic Pathways of Escherichia coli: Relationship between Flux and Control at a Branch Point, Efficiency of Conversion to Biomass, and Excretion of Acetate Current Topics in Cellular Regulation. ,vol. 28, pp. 69- 105 ,(1986) , 10.1016/B978-0-12-152828-7.50004-4
L. W. Enquist, Thomas J. Silhavy, Michael L. Berman, Experiments With Gene Fusions ,(1984)
John W. Frost, Enhanced production of common aromatic pathway compounds ,(1991)
B R Bochner, M A Savageau, Generalized indicator plate for genetic, metabolic, and taxonomic studies with microorganisms. Applied and Environmental Microbiology. ,vol. 33, pp. 434- 444 ,(1977) , 10.1128/AEM.33.2.434-444.1977
R Patnaik, J C Liao, Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield. Applied and Environmental Microbiology. ,vol. 60, pp. 3903- 3908 ,(1994) , 10.1128/AEM.60.11.3903-3908.1994
J C Cordaro, T Melton, J P Stratis, M Atagün, C Gladding, P E Hartman, S Roseman, Fosfomycin resistance: selection method for internal and extended deletions of the phosphoenolpyruvate:sugar phosphotransferase genes of Salmonella typhimurium. Journal of Bacteriology. ,vol. 128, pp. 785- 793 ,(1976) , 10.1128/JB.128.3.785-793.1976
P.R. Srinivasan, David B. Sprinson, 2-Keto-3-deoxy-D-arabo-heptonic acid 7-phosphate synthetase. Journal of Biological Chemistry. ,vol. 234, pp. 716- 722 ,(1959) , 10.1016/S0021-9258(18)70161-0
Milton H. Saier, Fred G. Bromberg, Saul Roseman, Characterization of Constitutive Galactose Permease Mutants in Salmonella typhimurium Journal of Bacteriology. ,vol. 113, pp. 512- 514 ,(1973) , 10.1128/JB.113.1.512-514.1973
Ranjan Patnaik, Richard G. Spitzer, James C. Liao, Pathway engineering for production of aromatics in Escherichia coli: Confirmation of stoichiometric analysis by independent modulation of AroG, TktA, and Pps activities. Biotechnology and Bioengineering. ,vol. 46, pp. 361- 370 ,(1995) , 10.1002/BIT.260460409
Celeste Yanisch-Perron, Jeffrey Vieira, Joachim Messing, Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors Gene. ,vol. 33, pp. 103- 119 ,(1985) , 10.1016/0378-1119(85)90120-9