Compositions and methods for inducing vasorelaxation

作者: Meir S. Sacks , Knox Van Dyke

DOI:

关键词:

摘要: A composition comprising one or more nitric oxide donors and an antioxidant is disclosed. The donor of the present invention provide a substrate for generation oxide; coupled with antioxidant, compositions therefore serve to raise levels in patient while minimizing peroxynitrite production. As result, vasorelaxation vasodilation experienced without tissue cellular damage associated other methods NO generation. Methods treating illnesses which vasoconstriction occurs symptom are also generally comprise administering concurrently sequentially be treated amount effective induce desired level vasorelaxation.

参考文章(7)
Manuel Worcel, Joseph Loscalzo, Michael D. Loberg, Joseph A. Vita, Methods of treating vascular diseases characterized by nitric oxide insufficiency ,(2001)
Henry H. Ting, Farris K. Timimi, Elizabeth A. Haley, Mary-Anne Roddy, Peter Ganz, Mark A. Creager, Vitamin C Improves Endothelium-Dependent Vasodilation in Forearm Resistance Vessels of Humans With Hypercholesterolemia Circulation. ,vol. 95, pp. 2617- 2622 ,(1997) , 10.1161/01.CIR.95.12.2617
Pushkaraj J. Lad, Liebel A. Marcia, Arnold A. White, Activation of rat lung soluble guanylate cyclase by sodium nitroprusside: effects of hemoglobin and reducing agents. Biochemical and Biophysical Research Communications. ,vol. 103, pp. 629- 637 ,(1981) , 10.1016/0006-291X(81)90497-6
Sergey Dikalov, Bruno Fink, Mikhail Skatchkov, Eberhard Bassenge, Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C. Free Radical Biology and Medicine. ,vol. 27, pp. 170- 176 ,(1999) , 10.1016/S0891-5849(99)00066-0
Stefano Taddei, Fabio Galetta, Agostino Virdis, Lorenzo Ghiadoni, Guido Salvetti, Ferdinando Franzoni, Costantino Giusti, Antonio Salvetti, Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation. ,vol. 101, pp. 2896- 2901 ,(2000) , 10.1161/01.CIR.101.25.2896