Ultramarathon and Renal Function: Does Exercise-Induced Acute Kidney Injury Really Exist in Common Conditions?

摘要: Background: Increasing ultramarathons participation, investigation into strenuous exercise and kidney function has to be clarified. Study design: Prospective observational study. Methods protocol: The study used data collected among ultra-marathon runners completing the 2017 edition of 120 km “Infernal trail” race. Samples were within 2 hours pre-race (start) immediately post-race (finish). Measurements serum creatinine (sCr), cystatin C (Cys), creatine kinase, urine albumin completed. Acute Kidney Injury (AKI) as defined by RIFLE criteria. ”Risk” injury was increased Creatinine (sCr) x 1.5 or Glomerular Filtration Rate (GFR) decrease > 25%. sCr GFR 50%. These two categories AKI combined calculate total incidence at finish line. estimated methods, using measure C. Urinary biomarkers (neutrophil gelatinase-associated lipocalin (NGAL)) also define AKI. Outcome results before after race compared McNemar test for qualitative Wilcoxon signed-rank quantitative data, in modified intent-to-treat per-protocol analyses. Results: A sample 24 included finishers, with no use non-steroidal anti-inflammatory drugs (NSAIDs) studied. Depending methodology GFR, prevalence observed from 0 12.5%. damage following but significant GFR. Discussion/Conclusion: Our showed a very low evidence that ultra-endurance running can cause important properly hydrated subjects NSAIDs. Whether increase urinary reflects structural simple metabolic adaptation needs