Methods for treatment of cervical insufficiency

摘要: Methods, compositions, devices and kits for increasing mechanical stiffness of an incompetent or a dilated biological tissue in subject are provided herein. The methods described herein involve placing (e.g., injecting) silk fibroin-based composition into at least portion subject. In some embodiments, the can further comprise two PEG components that will crosslink together upon placement injection) need thereof. specific methods, be used to increase cervical subject, example, treatment insufficiency.