Combinations of sesquiterpene lactones and ditepene triepoxide lactones for synergistic inhibition of cyclooxygenase-2

作者: John G. Babish , Linda Pacioretty , Terrence Howell

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摘要: A novel formulation is provided that serves to inhibit the inflammatory response in animals. The comprises, as a first component an effective amount of diterpene triepoxide lactone species and second sesquiterpene or derivatives thereof, provides synergistic anti-inflammatory effects physical chemical injury abnormal immune stimulation due biological agent unknown etiology.

参考文章(19)
W. J. PUGH, K. SAMBO, Prostaglandin synthetase inhibitors in feverfew. Journal of Pharmacy and Pharmacology. ,vol. 40, pp. 743- 745 ,(2011) , 10.1111/J.2042-7158.1988.TB07010.X
Peter M Bork, M.Lienhard Schmitz, Michaela Kuhnt, Claudia Escher, Michael Heinrich, Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF‐κB FEBS Letters. ,vol. 402, pp. 85- 90 ,(1997) , 10.1016/S0014-5793(96)01502-5
Hector R. Wong, Ingrid Y. Menendez, Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells. Biochemical and Biophysical Research Communications. ,vol. 262, pp. 375- 380 ,(1999) , 10.1006/BBRC.1999.1207
Xuelian Tao, Hendrik Schulze-Koops, Li Ma, Jian Cai, Yanping Mao, Peter E. Lipsky, Effects of Tripterygium wilfordii hook F extracts on induction of cyclooxygenase 2 activity and prostaglandin E2 production. Arthritis & Rheumatism. ,vol. 41, pp. 130- 138 ,(1998) , 10.1002/1529-0131(199801)41:1<130::AID-ART16>3.0.CO;2-4