Intracellular Responses of Neurons in the Mouse Inferior Colliculus to Sinusoidal Amplitude-Modulated Tones

摘要: Changes in the temporal envelope are important defining features of natural acoustic signals. Many cells inferior colliculus (IC) respond preferentially to certain modulation frequencies, but how they accomplish this is not yet clear. We therefore made whole cell patch-clamp recordings IC anesthetized mice while presenting sinusoidal amplitude-modulated (SAM) tones. The relation between number evoked spikes and frequency was used construct rate transfer functions (rMTFs). observed different types tuning, including band-pass (16%), band-reject (13%), high-pass (6%), low-pass (6%) tuning. In rMTF neurons some neurons, tuning characteristics appeared be already present inputs. both nonlinear membrane potential spike probability ensured preferential spiking during only a small part period. Band-pass had rapidly rising excitatory postsynaptic potentials, allowing good phase-locking brief tones intermediate frequencies. At low adaptation their threshold contributed onset response. contrast, responded with or inhibitory potentials these cells, power law could describe supralinear average rate. Differences timing synaptic input presence absence define SAM mouse IC.